I have played both Archon & SNS specs in the past and got burnt out on wiz so decided to level a Witch Doctor and was having a blast with Plague Bats, then I saw a video with that pro Wiz Jaetch trying something a bit different with his Ninja Wizard Build, so it gave me a little inspiration to try something different myself for the heck of it. Forgive my ignorance if in fact this particular build has been tried before but after some experimenting this seemed to work decently for me on mp10 with fast clear times in the areas I tested (Fields of Misery, Weeping Hollow, Vota, Festering Woods).
After trying out several combinations of gear with different stats, the link to my profile http://us.battle.net/d3/en/profile/vipes-1257/hero/23860703 seemed to be the most effective combo of gear and abilities that ensured good survivability, sustain and DPS. From several runs tweaking, the changes that seemed to help the most were
15 to 20 APOC
Lifesteal of 2.5 % or more on Weapon along with 1.5% LS from Blood Weapon, Skorn users can skip this and go for the additional 5% damage
800 to 1000 LOH
Astral Presence Passive
4000 Armor (unbuffed)
650 AR (unbuffed)
Basically your main damage dealer will be Disintegrate with the Entropy rune which functions similar to the Witch Doctor's Plague Bats but without the dot, the coefficient for LOH on entropy is 1.00 which gives you great sustain along with the LS to basically stand in place and faceroll elites or white mobs pretty easily. I used blizzard with stark winter to pull mobs in and also to boost damage with cold blooded, this also helped mobs come into the cone a lot slower, allowing more dps time overall and saving me from taking damage.
My CC with scoundrel is 55% which allowed me to burn down most packs on MP10 without running out of AP , on the rare occasion I did find myself out of AP a short 1 to 3 Second Burst of Living Lighting quickly refilled my bubble, I think another skill can probably be used in its place since it was rarely used in most of my runs. Results may vary according to gear and MP level but any further tweaking or advice on how to make the build better will surely be welcomed.
If this works for any of my fellow wizards then I am happy to have given something back to this outstanding community which has helped me learn so much about this game and all of the classes I have played. Hope you have as much fun as I am having shredding monsters with this build!