I look at it this way.
At 60, you'll want one build and one build only otherwise you lose NV.
There are so many good skills for a barb to take you really want to take just 1 main fury generator.
Those are cleave, bash, or frenzy.
I love the 20% stun chance rune on bash, but just hitting things isnt cool. Who wants to stunlock a million zombies to death? So we have frenzy and cleave.
Cleave: A crude average of hitting 2 monsters at a time, deals 220% dmg per hit.
Frenzy: Does 110% dmg per hit, but will hit 0.75 times more than cleave.
So far, fury winning vs single target, cleave winning for overall dmg output.
But what are we really talking about here? Running rares, champs, and bosses right? So you want to be able to single target. If you're able to hit 2-3 rares, then 2-3 rares are able to hit you, and that = dead.
Thus my builds are more frenzy, with a few good aoes (revenge, overpower, ground stomp), based.
As for runes, I say sidearm. Triumph only works if frenzy kills it, vanguard = meh, smite is worse than bash stun, mainiac could be the clincher if it does all damage. However sidearm adds 27.5% weapon dmg per hit, and at max atk speed bonus it gets even better overall. Also it gives you some aoe on your basic attack which doesnt lose anything vs single targets.
EDIT: Typos and the dumb.
Edited by D3BETA on 4/3/2012 6:08 PM PDT