Frenzy: Single target damage with stun. I believe the increased attack speed and stun will be key in dealing with elites and bosses depending on how their resists works. If bosses have a reduced timer then the stuns will still serve as valuable interrupts. However, if they have a reduced chance to be stunned then I may go with a different rune.
Seismic Slam: Far reaching AoE damage for the masses with knockback. Hopefully I will be able to engage enemies from far away and use the knockback to keep them at a distance until they are close to death. The longer I can keep them off me the less damage they can do. I have it runed for fury reduction to increase its spamability.
Threatening Shout: A must have for Barbarians. Reduces incoming damage and increases drops.
Furious Charge: I made a change to Furious Charge because I was having a hard time imaging how fights would go from a fury generation standpoint. I felt like I may have been able to Frenzy down left over mobs to get a good amount of fury and then rush to the next group before it started draining. That may have worked, but this just seems better. Plow through, slam... plow through, slam... I'll be able to keep my distance and still do good damage. It also gives me an escape if I happen to get surrounded.
Earthquake: 250% damage/sec. I think this will be very good at dealing with overwhelming odds as well as provide a damage boost for taking down rare/boss mobs quickly.
WotB: Strictly for dealing increased damage to rare/boss mobs.
Nerves of Steel: A large hp pool will be needed to survive in Inferno. Using this passive will make vitality stacking increase armor as well for a double boost to survivability.
Relentless: Having a large hp pool will also provide me with a wider range for Relentless to work in. Taking 50% less damage while under 20% may be just what is needed to go from certain death to being able to maintain with life leech.
Weapons Master: Im going to keep this in for increased damage since, but I may switch it out for Tough as Nails if I decide to use a two handed weapon instead of a shield.