Was dual wielding swords on my Monk (Nightmare Act 3) and decided to change to a sword/shield for the fight with Cydaea (spider lady) I clicked the accept button to go into the boss as I was changing items, I believe the sword was still 'floating' (attached to my cursor, not yet placed back in the stash) and then the load-in happened. I lost the sword I was holding, however, the shield was still in place. Frustrating to lose my offhand weapon, to be sure :(
Edited by Overnight#1155 on 5/21/2012 4:06 AM PDT