There is a known stuttering issue caused by "loading assets". It is so drastic that it kills the gameplay and it lasts like 1 hour then when I change the skill or when I find a new weapon with different elemental damage on it or when I go to different place it begins again. Anyway
As far as I can see, this issue is generally on laptops. (though I may be wrong) I have a monster laptop that runs Crysis 2 and BF 3 on high details without any problem or without any stuttering but can`t play Diablo 3 smoothly.
So I wonder if Diablo 3 is fully compatible with notebooks or not. If it`s not then Blizzard should have said that in the system requirements before we wasted our 60$