Worst. Idea. Of. My. Life.
Used it against the Skeleton King in Hell, didn't die of course, but it was the absolute worse thing I've ever done. I forgot how much Chakrams sucked because they only would take out half the pack and did !@#$ty damage on top of that. Impale was great like it always is, until I ran out of hatred. Grenades has to be the absolute worst hatred generator ever. The damage is crap, they take forever to bounce out there, and half the time all of the grenades won't hit. If you're trying to throw from a range at all, the spread is giant by the time it reaches the enemy. The fight lasted forever and if it had been hard at all (I mean, come on, it was only the skeleton king) I probably would have been face-down halfway through the fight.
Moral of the story, unless you have a melee weapon that increases your dps by over double: don't even consider using. And in that situation, consider using it, but don't do it.