I have soloed basically everything all the way up to here (yes, even entire act 3 all the way post ss nerf patch), but have hit a total brick wall at Azmodan (talking over 50 tries and failing). For this few reasons.
1)There is no casting animation at all whenever the pools (Hell's grasp) spawn, hence there nothing to anticipate for possible kiting.
2)The pools seems to be casted directly on your character in solo after the initial few random pools
3)The pools are instant kill for a DH not in smoke-mode regardless of gear.
Act 2 and 3 became a lot tougher after the SS nerf, but it is still doable with proper kitting (and skipping soul lasher elite mobs), but this is a total brick wall. Any one else has done it post-patch?