I confirm MASSIVE lag spikes between my home desk computer (Digital Storm) that is wired and my work office computer (Digital Storm) that is wireless. Massive latency spikes, from sub 200ms to over 2500ms.
How I ever made it through Inferno Act 1, I don't know. Most times, as of today, I'm dead and it takes 5-10 seconds to confirm it. That, or I get error 3007 saying I've dc'ed, etc.
I dealt with this during the early WOTLK WoW days, but I expected that. I never really expected that during D3, especially since I chose Diablo because it wasn't meant to be an unplayable MMO. We have much of the problems of WOW, but few of the benefits they receive (for starters, a reasonable and decent AH; this AH system is horrible).
I do expect a solid patch tomorrow, as the game is unplayable in its current form. At least in WOW I could dump out of raids and PVP, level alts, craft, explore, or even veg out. Diablo doesn't afford that sort of 'relaxed' play, so any latency is game killing. I wouldn't even start a Hardcore character until we know these issues are resolved (which I anticipate they will be). It's just sad to see my barbarian trotting along, ok latency, then BAM! treasure gob or champ pack and I'm dead on site.
Here's to hopping it works, because I have Verizon at home and Comcast at work and NEITHER function properly.