I'm still farming Act 1 Inferno, and the +%crit damage/Sharpshooter/2H Crossbow seems the best choice for the undergeared beginning to farm. I may change my mind if I obtain two good 1-handers, but I have horrible luck and are relying heavily on the AH to gear up, therefore I've put more money into good +resist gear to help my survivability so that I can reliably farm Champs and Elites for more cash. +%Crit damage seems easier to come by, and my kiting style involves dragging mobs over Long Fuse traps...this relies a lot on the high chance for those traps to crit thanks to Sharpshooter, and the additional crit damage means I get three 150k damage hits on mobs with each clump of traps (while spamming Hungering Arrow/Piercing from the edge of the screen :3)
Since weapon DPs seems to be the biggest determinant of damage done, it's probably best to look at whether or not the highest-end 1H combos net as much DPS as a 2H+quiver, before considering other modifiers.
I'm kinda getting bored of my demon hunter's crit damage build and i used to love the speed that my demon hunter had back in hell before lvl 60 but i'm trying to find a definite path to go down and not have to worry about the other path that i didn't.
It's not like you have to remake the character...you just farm up more gold to try out the other set, and weigh them both. I wouldn't worry so much about time wasted on gathering another gear set...this game doesn't really seem like a race to the finish, to me. 'Progression' relies on how quickly you can obtain the gear you need to survive encounters, and that's luck-based with an upper limit on how much time you have to play in the first place. I'm happy !%!*ing around in Act 1 Inferno for gold to fine-tune my gear. It was hard at first but now that I've replaced a few pieces it's ridiculously easy to farm if you can stomach the monotony.
What's your goal? I think that the things you plan to do later in the game would also have a big impact on what kind of playstyle and thus gear set would best suit it.