This occurs at extremely random times, but usually within 5 minutes of starting Diablo 3. Occasionally I get the crashes when I'm not even doing anything but opening my web browser. I have NEVER even once, had an issue with my graphics card before Diablo 3. I have tried [literally] everything on the Diablo III Lockups and Crash Troubleshooting guide and Diablo III Video Performance Issues Guide, and the crashes persist. I have tried reformatting my hard drives, rolling back drivers (and of course updating to the most recent), re-installing, resetting to factory defaults on hardware, flashing my bios... The list goes on; nothing works. Sometimes, I'm able to play the game without ever having a problem for hours (this is quite rare, usually just once every 2-3 days), and the next day, without changing any settings, I start up Diablo 3 and the computer crashes again. The issue is absolutely NOT heat related, in fact I have a photo of the game in windowed mode with a hardware monitor in the background that says the GPU sensor is at 60c while playing.
I have been troubleshooting for about 5-6 days now, and nothing has helped yet, besides taking out the graphics card. I submitted a ticket on 5/30 and it hasn't been responded too yet, which is interesting considering I had another ticket submitted 30 minutes post on an unrelated topic that was answered yesterday. Thanks for any help.
Hardware is as follows:
AMD Athlon 7750 Black Edition
MI-A78S-8209 Motherboard (XFX GeForce 8200 Chipset)
8gb of OCZ DDR2 6400 400Mhz RAM
BFG Tech NVIDIA GeForce GTX 280
Running Windows 7 Ultimate 64-bit
Edit: I should add that I have never had a hardware problem since I built this computer about 3 years ago, nor a problem with this graphics card in 2 years.