Butcher runs usually means a lot of vendor loot and rarely any upgrades, so if you want to farm gold, I guess this is the place. You could get about 60-100k per run.
Every act has an item pool of items dedicated specifically to that act only. But there is also a shared loot table for all of the acts, but it has a very low drop rate ( For example Act 1 loot can appear in Act 3 and vice versa, but the former is more common)
If you are looking for upgrades and not just gold, I'd suggest act two. The odds are just better.
Zoltun Khule runs are easy and have recently dropped me some pretty OP gear.
I've had less great drops from Seigebreaker runs than I have from Zoltun runs. At least less useful ones. I get Tanking stuff from Seigebreaker that I sell for good gold but seems more DH stuff from khule haha.
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