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If you have pain in your hands it's most likely your hand and not the mouse.
You can try a mouse with the ball (where you don't have to move the mouse)
They give much less strain but take a while to get used to using, I used to use one and the first month was rough but after that it was smooth sailing.
I use a razor death adder right now and love it.
Something else I've noticed that helps a lot is making sure you are at the right level with your desk and make sure you're not pressing your wrist on the edge of your table/desk.
I also have one of the gay mouse pads with the jelly wrist guard, that has helped me too.
Hope you can figure it out I know how annoying it can be when your wrist / hand hurt just from gaming.
If you don't get much activity lifting some light weights might help your hand strength and in turn cause you less pain in long gaming sessions. (last one is just a random suggestion)
Try the Cyborg R.A.T. 7. It's hardware is fully customizable to fit different types of hands. The thumb plate, pinkie finger plate, palm rest, and total weight can all be adjusted. I use it and haven't touched another mouse since.
Edited by Bukizzle#1560 on 7/24/2012 11:18 AM PDT
Been using a Razer Naga, I have really liked the feel of it. If you have a Best Buy near you they may have one on the shelf you could try getting the feel of it to see if you like it...
Edited by Antiquarian#1163 on 8/2/2012 7:54 PM PDT
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