My main build is a Witch Doctor. The challenge all the affixes present is appreciated, including those that require more movement/repositioning (Waller, Mortar, Vortex, Desecrator, Teleporter), and those which require being selective when upgrading gear. Reflect damage, for example, is countered by life regeneration and health globe pick-up radius until a weapon with life steal can be obtained.
Even when combinations such as Jailer, Desecrator and Frozen happen with quick succession of any sequence, and all you can do is watch your character's health deplete while causing as much damage to opponents as possible before it is gone, such is not a significant issue. After all, the possibility of not dying uncontrollably every so often would become boring. Trying to evade it happening to greatest extent possible is the interesting part, you know ... like real life!
Though, if there were one affix I could change, it would be Arcane Sentry. To my mind, Diablo and laser beams just don't equate. It's not a complaint, just an observation. The mechanics of the affix add another appreciable challenge, appearance and concept are the issue. Alternatively, the affix could be renamed Arcane Void. The color could be changed to primarily black with sickly golden-yellow moving from the edge of the rotating pulsar to the center. The center could be considered a type of singularity, drawing energy/life from the mortal world into the hells.
Anyway, that's my half baked thought for the day!
Edited by MonTerran#1251 on 11/2/2012 10:24 AM PDT