@Ana You mean missing out on 100% damage only. Please do keep in mind that Calamity has the chance to roll 100% crit dmg on itself and it can roll a socket. You will only miss out maximum 150% damage including passive.
I personally prefer Calamity. It provide a greater variation of style and flexibility in play style with a little sacrifice on burst damage count. U do more hits, generate hatred faster, put out hatred faster, deal more small damage in a short time which amount out to almost the same damage as burst damage.
I agree while Manticore offers more burst damage, it is not really good in the sense of utility. I am using Calamity with the Gloom + Spike Traps - echoing blast and I am blasting my way through mp5 without a problem tanking the monsters at 78k dps. Inferno mp6 take a little more work and concentration, it is plausible, but for molten/arcane/desecrator combos, it will take some time. And the fact that I am doing more hits of lower damage , I can practically out live RD elites without much problem with a little kitting. Whereas, most Manticore users probably just blow themselves out with their own burst skill only to find out that that elite is RD IMHO.
This is my skill choice :http://us.battle.net/d3/en/calculator/demon-hunter#WQhdgk!Xfe!YaZcYc
Note that most of my resistance dont even reached 300 baseline.
I have reasons for the trail of cinders if you ask me. Turn Gloom on and roll over an enemy and see your life recover! It is the only skill that ticks that fast for DH. I always use it to balance out my life if I am not able to sustain my life tanking too much monster at a time and provide me a way out of the raging mob. Combining my equipment with the speed of shooting out my bola shots and putting out my spike traps. My discipline is almost never empty. I tried using it without legacy nats and I am pretty confident to say that if you have at least 2.86 atk speed with decent armor, life and damage, you can tank like a monk. Hear me, like a monk. Meaning, you can only endure hits from mobs but not long period on desecrator, never on arcane, a little on molten and briefly on poison pool. Always avoid them, use vault whenever necessary.