I know I'll have to bring it down a bit, but it still made me unsure on my general strategy, so i thought i'd ask here.
I'm using Frenzy/Smite to deal with single targets, stunning them so they can't hit back.
With groups I pull them together with Ground Stomp/Wrenching Grasp and then Whirlwind/Wind Shear them. Only use that rune so i don't need to stop. If they survive it I used Leap/Death from Above to stun them again and go for a second round. Against tough single enemies i'll use these to also keep them stunned.
If they still don't die at this point or i'm in a generally troublesome situation, Ignore Pain/Ignorance is Bliss to get my health back and/or run away.
For anything especially tough i drop Earthquake/Chilling Earth.
I use Tough as Nails to up my defences and (mainly) to increase my Thorns damage (29760 total).