With all the outpouring of interest in this thread I'm hoping this can become a haven for people looking to branch out from the cookie cutters. There's nothing wrong with those, they get the job done for farming, but I always felt like the point of cookie cutters was to make possible builds like these (by obtaining the wealth you need to make them). I hope everyone who feels this way can come to this thread for new and interesting builds, and if I come up with any I'll post 'em.
Oh, this one is fun: fetish summoner WD.
Instead of using the fetish skill you combine the fetish sycophant passive with extremely high attack speed. Generally when I'm doing runs I have at least four and sometimes as many as seven or eight fetishes at any given time.