The launcher opens fine but when I click play I get the skull, a black screen, and then the game stops responding and I have to force quit it. I don't have the debug file on me right now but I can say for certainty that the error appears right below the "Initializing sound subsystem" line which leads me to believe that the game for some reason can't find my sound drivers and therefore crashes.
I've tried the usual things suggested, none of the below have worked:
Deleted the mfil file
Deleted Battle.net folder
Deleted the cache folder
Reinstalled the game
Changed DNS settings
Opened all required ports
Reinstalled my OS (OS X 10.8.2)
Ran a Hardware Test (nothing came up)
and probably a lot more that I can't recall. There's nothing I can seem to do in order to fix this problem so I'm desperate at this point. I know my mac is capable of running it and every other game (WoW, Skyrim, Portal, TF2, etc) installed runs fine but D3 won't work.
If you want some debug files or profiler just ask and I'll try to get them up when I'm on my iMac. I'm willing to do just about anything at this point.