All depends on how you like to play.
For damage your only real option is to go bears, if you have a ton of LOH you can use Acid Cloud Acid Rain and get insta health refil. Both of these builds use Rain of Toads as a complimentary skill. Acid Cloud and Toads have the highest proc rates for LOH, stun, etc.
You can also use a Spirit build (this is what I used to play through), which is pretty fun:http://us.battle.net/d3/en/calculator/witch-doctor#egUXYT!afe!cZcYbc
On the secondary skill side, pets will get you pretty deep into inferno, only molten takes them out and they tank like a bawss which is nice solo or in a group.
Targets to shoot for as you approach and pass 60 would be 400K ehp and 40K dps from what I've seen in other threads. I lean more defensive so I like 650 to 750 ehp and dps in the 30s.
Only other thing to be careful with is attack speed, too much of it and you burn up your mana, to little and your cast animations are really slow. In general, it's the last thing you wanna worry about.
Good luck with your WD.