This is not a disappearing issue. Saw several threads about one, so thought I'd say that right away.

So to my issue...

I use an Apple Mighty Mouse. Nothing is wrong with it, as far as I know. Cursor moves around just fine. Click responsiveness is just fine when in WoW, Firefox, Photoshop, etc. But in D3, I find it delays in my clicks at times. For example, when I'm playing my demon hunter and I try using my right-button ability, it activates the left-button ability. Both are attacks, so it's not a huge deal... until I fight vs a boss or rare/magical spawn. Then not activating the right attacks when I want can result in death.

So knowing the mouse works fine in every other app I've tried, is this an issue with D3 or is it actually my mouse?