What are the monsters/quests you always skip or always kill? Unless I'm doing a speed run only looking for elites or the KW, I always kill trees in act 1. You could replace Diablo's profile with one of Old Man tree, and the game would feel about right in terms of difficulty. If I see a tree, I make sure I kill it... BUT, if I see the Old Man tree quest, I skip that faster than hopscotch.
Sure I get killed by bulls every now and then... act 2 blazing (fire) guardians are a pain in the !@#.. act 3 tremors or heralds of pestilence are all equally as bad... but trees are still #1.