For the first few levels I was trying to use what I thought were reasonable witch doctor weapons, a dagger and a fetish. Then I found a blue spear and equipped that with a shield. After killing the skeleton king I received a really nice 2 handed sword, I was really surprised by how much more damage my spells did with that big bastard equipped. So my question is, should I just be using the highest DPS main hand I can find? I obviously never swing it so speed etc doesn't matter. I imagine once I am up to nightmare mode etc a shield will probably be a nice thing to have but right now I am "One Darting" damn near everything I see.
you dont ever "use" your wep so go with whatever drops that is high dps/has good stats for you