Just started playing the game, got past Hogger and when I was on the second "tutorial" mission I thought I'd check out the graphics options.
I changed the graphical setting from medium to high and instantly my screen went white with green/red/blue/yellow lines randomly places on the display. I could hear the game sounds, and when I clicked I could tell Im clicking on buttons but I had to Quit the app (command+Q)
Right afterwards a patch downloaded and I'll start it again now and see whether it happens again.
This was on an iMac with a 3.06 GHz i3
4 GB Ram
running 10.8.4 OSX
and an ATI Radeon HD 4670 256 MB gfx card.