I'm running the game on a three screen system(1920x1200 24", 2560x1440 27", 1920x1200 24") with the primary screen set to the middle one. In windowed mode, if I move the window from the primary (center) screen to the right screen, the game offsets the mouse pointer from where it appears. To select a card (or just hovering to zoom it in), I have to place the pointer far above the card itself. The mouse pointer graphic appears in the correct location (ie, it doesn't jump when moving across the game window borders), but the place where the game thinks the mouse is placed is roughly 30-40% of the game window below where it appears to be.
After moving the game window back to the primary screen, it works as expected again without needing to restart the game.