I've got an issue with the audio, although it's not terribly game breaking. Whenever a special unit (Raynor, Kerrigan, etc) speaks- both during a campaign and on the Hyperion- the audio acts weird. When on the Hyperion, if I start a dialogue with someone and the camera cuts away from them, their audio will drop to almost nothing. When in the campaign, their voice seems to be bound to the area I was looking at when they started speaking- for example, Kerrigan was speaking to me when I was shuffling units inside my base, and when I moved to a different section of the map while she was talking, her audio volume plummeted.

I'm using a Creative SoundBlaster X-Fi sound card with 5.1 speakers. All my drivers are up to date, and it seems to work more than fine with other programs.