Wow, this whole thread is full of fail keybindings. I have not seen one good list yet.
Let's see your layout!
Edit: Also ESDF instead of WASD is crucial. WASD sucks. ESDF opens up keys to the left and right of your hand. After that, it's just a matter of comfortably binding abilities to the surrounding keys and making liberal use of macros. If you're forced into a situation of uncomfortable keybindings, just make sure they're at least set to abilities with long cooldowns or are low priority.