Let's do some math.
1 trillium bar=4 trillium ore and if the average node is three ore then that 1.25 node per bar.
1 trillium bar=10 ghost iron bar (via alchemy transmute)=20 ghost iron ore which is roughly 4 ghost iron nodes per trillium bar.( I say 4 nodes because a regular GI node is 3 ore but a Rich Ghost Iron ore is 5.5.)
Now, trillium nodes don't spawn at a 33% clip so this is imbalanced because it makes trillium nodes pointless. It's far more efficient to mine ghost iron and then transmute it rather than mine trillium (not to mention that silly black/white mechanic.)
Either the alchemy transmute needs to get a CD or
Ghost Iron needs to be nerfed or
trillium nodes need to be buffed.
As it stands right now miners get to mine one thing this expansion: ghost iron. All the rest is basically irrelevant.