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Dark Regen is pretty darn nice and I would consider it mandatory for PvP but the others can be and are absolutely fine if you are just talking about PvE. It is more personal preference than anything. Active skill coupled with AOE damage, use Harvest Life. Don't want yet another skill to monitor that deals small amounts of passive healing, use Soul Leech. Big active healing but with a cooldown, use Dark Regen.
I though you were talking about PvP for some reason. Dark Regen isn't mandatory in PvE, but I'd still go with it over the others unless you have a specific reason for using Harvest Life. Damage tends to come in bursts in PvE, so using Dark Regen during those points will help your healers more.
its especially good while leveling. There's a lot more AOE and its just a lovely thing. IDK what i wouldve done without it while leveling.
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