Alextrasza herself had suffered more than most. Not only had all her eggs been destroyed by Korialstrasz-in the act of sacrificing himself-to prevent their corruption into the monstrous twilight dragons, and her ability to lay more eggs have been forever taken away, but in attention to all that she lived with the knowledge that the other dragon flights had suffered so. She might have accepted her loss of power, but not this loss of her kin's future. After all, she had been the Life-binder.
That's probably part of the massive depression she's going through.
Poor Alex has been through a trauma conga line. Her son dies, her husband dies, dozens of her children die, she turns mortal, now she can't have children ever again.